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The 100 most highly cited papers of all time

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To mark the anniversary, Nature magazine asked Thomson Reuters to list the 100 most highly cited papers of all time. The search covered all of Thomson Reuter’s Web of Science, an online version of the SCI that also includes databases covering the social sciences, arts and humanities, conference proceedings and some books. It lists papers published from 1900 to the present day.

 
Title of the paperRankSubject
The assessment and analysis of handedness: the Edinburgh inventory.61Psychology/psychiatryShow more
Estimation of concentration of low-density lipoprotein cholesterol in plasma - without use of preparative ultracentrifuge.62MedicineShow more
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.63Biology lab techniqueShow more
Multiple range and multiple F tests.64Mathematics/statisticsShow more
Electric field effect in atomically thin carbon films.65PhysicsShow more
Tissue sulfhydryl groups.66Biology lab techniqueShow more
Isolation of mononuclear cells and granulocytes from human blood.67Biology lab techniqueShow more
The measurement of observer agreement for categorical data.68Mathematics/statisticsShow more
Crystallography & NMR system: a new software suite for macromolecular structure determination.69CrystallographyShow more
Gaussian-basis sets for use in correlated molecular calculations. 1. The atoms boron through neon and hydrogen.70Mathematics/statisticsShow more
PROCHECK: a program to check the stereochemical quality of protein structures.71CrystallographyShow more
The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection.72MedicineShow more
A new look at statistical-model identification.73Mathematics/statisticsShow more
Improved M13 phage cloning vectors and host strains — nucleotide-sequences of the M13mp18 and pUC19 vectors74Biology lab techniqueShow more
A comprehensive set of sequence-analysis programs for the vax.75BioinformaticsShow more
MODELTEST: Testing the model of DNA.76BioinformaticsShow more
From ultrasoft pseudopotentials to the projector augmented-wave method.77Physical chemistryShow more
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.78Biology lab techniqueShow more
Comparison of simple potential functions for simulating liquid water.79Biology lab techniqueShow more
The development and use of quantum-mechanical molecular-models. 76. AM1: a new general-purpose quantum-mechanical molecular-model80Physical chemistryShow more
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