The 100 most highly cited papers of all time

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To mark the anniversary, Nature magazine asked Thomson Reuters to list the 100 most highly cited papers of all time. The search covered all of Thomson Reuter’s Web of Science, an online version of the SCI that also includes databases covering the social sciences, arts and humanities, conference proceedings and some books. It lists papers published from 1900 to the present day.

Title of the paperRankSubject
Protein measurement with the folin phenol reagent.1Biology lab techniqueShow more
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.2Biology lab techniqueShow more
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.3Biology lab techniqueShow more
DNA sequencing with chain-terminating inhibitors.4Biology lab techniqueShow more
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.5Biology lab techniqueShow more
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.6Biology lab techniqueShow more
Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density.7Physical chemistryShow more
Density-functional thermochemistry. III. The role of exact exchange.8Physical chemistryShow more
A simple method for the isolation and purification of total lipides from animal tissues.9Biology lab techniqueShow more
Clustal W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting - position-specific gap penalties and weight matrix choice.10BioinformaticsShow more
Nonparametric estimation from incomplete observations.11Medical statisticsShow more
Basic local alignment search tool.12BioinformaticsShow more
A short history of SHELX.13CrystallographyShow more
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs.14BioinformaticsShow more
A revised medium for rapid growth and bio assays with tobacco tissue cultures.15Biology lab techniqueShow more
Generalized gradient approximation made simple.16Physical chemistryShow more
Mini-mental state: A practical method for grading cognitive state of patients for clinician.17Psychology/psychiatryShow more
A rapid method of total lipid extraction and purification.18Biology lab techniqueShow more
Detection of specific sequences among DNA fragments separated by gel-electrophoresis.19Biology lab techniqueShow more
The neighbor-joining method: A new method for reconstructing phylogenetic trees.20PhylogeneticsShow more