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The 100 most highly cited papers of all time

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To mark the anniversary, Nature magazine asked Thomson Reuters to list the 100 most highly cited papers of all time. The search covered all of Thomson Reuter’s Web of Science, an online version of the SCI that also includes databases covering the social sciences, arts and humanities, conference proceedings and some books. It lists papers published from 1900 to the present day.

 
Title of the paperRankOggetto
Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method.21Biology lab techniqueVedi di più
Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides.22Physical chemistryVedi di più
Processing of X-ray diffraction data collected in oscillation mode.23CrystallographyVedi di più
Regression models and life-tables.24Medical statisticsVedi di più
Density-functional exchange-energy approximation with correct asymptotic-behavior.25Physical chemistryVedi di più
Colorimetric method for determination of sugars and related substances.26Biology lab techniqueVedi di più
Use of lead citrate at high pH as an electron-opaque stain in electron microscopy.27Biology lab techniqueVedi di più
The CLUSTAL_X Windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools.28BioinformaticsVedi di più
Statistical methods for assessing agreement between two methods of clinical measurement.29Medical statisticsVedi di più
Reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.30Biology lab techniqueVedi di più
Isolation of biologically-active ribonucleic-acid from sources enriched in ribonuclease.31Biology lab techniqueVedi di più
The attractions of proteins for small molecules and ions.32Biology lab techniqueVedi di più
The moderator–mediator variable distinction in social psychological-research — conceptual - strategic - and statistical considerations.33Psychology/psychiatryVedi di più
Self-consistent equations including exchange and correlation effects.34Physical chemistryVedi di più
Rapid colorimetric assay for cellular growth and survival — application to proliferation and cyto-toxicity assays.35Biology lab techniqueVedi di più
Helical microtubules of graphitic carbon.36PhysicsVedi di più
The colorimetric determination of phosphorus.37Biology lab techniqueVedi di più
Disc electrophoresis — II. Method and application to human serum proteins.38Biology lab techniqueVedi di più
Inhomogeneous electron gas.39Physical chemistryVedi di più
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.40Biology lab techniqueVedi di più
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