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Federal Register / Vol. 86, No. 43 / Monday, March 8, 2021 / Rules and Regulations 526.1130

Hetacillin.

a Specifications. Each single-dose, 10-milliliter syringe contains hetacillin potassium equivalent of 62.5 milligrams mg ampicillin.

d Conditions of use in lactating cows1 Amount. Infuse the contents of one syringe equivalent to 62.5 mg ampicillin into each infected quarter.
Repeat at 24-hour intervals for a maximum of 3 treatments.
2 Indications for use. For the treatment of acute, chronic, or subclinical mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus aureus, and Escherichia coli.

31. Revise 526.1590 to read as follows:

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526.1590

Novobiocin.

a Specifications. Each single-dose, 10-milliliter syringe contains:
1 150 milligrams mg of novobiocin equivalents as sodium novobiocin, or 2 400 mg of novobiocin equivalents as sodium novobiocin.
b Sponsor. See No. 054771 in 510.600c of this chapter.
c Related tolerances. See 556.460
of this chapter.
d Conditions of use for syringe described in paragraph a1 of this section in lactating cows1 Amount.
Infuse the contents of one syringe equivalent to 150 mg novobiocin into each infected quarter after milking.
Repeat treatment once after 24 hours. Do not milk for at least 6 hours after treatment.
2 Indications for use. For the treatment of mastitis caused by susceptible strains of Staphylococcus aureus in lactating cows.
3 Limitations. Milk taken from treated animals within 72 hours 6
milkings after latest treatment should not be used for food. Do not slaughter treated animals for food for 15 days following latest treatment. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
e Conditions of use for syringe described in paragraph a2 of this section in dry cows1 Amount. Infuse the contents of one syringe equivalent to 400 mg novobiocin into each quarter at the time of drying off.
2 Indications for use. For the treatment of mastitis caused by susceptible strains of Staphylococcus aureus and Streptococcus agalactiae in dry cows.
3 Limitations. For udder installation for the treatment of mastitis in dry cows
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only. Infuse each quarter at the time of drying off, but not less than 30 days prior to calving. Do not slaughter treated animals for food for 30 days following udder infusion.
32. Revise 526.1696 to read as follows:
526.1696

Penicillin G procaine.

a Specifications. Each single-dose, 10-milliliter syringe contains penicillin G procaine equivalent to 100,000 units of penicillin G.
b Sponsors. See Nos. 010515 and 061133 in 510.600c of this chapter.
c Related tolerances. See 556.510
of this chapter.
d Conditions of use in lactating cows1 Amount. Infuse the contents of one 10-milliliter syringe equivalent to 100,000 units penicillin G into each infected quarter. Treatment may be repeated at 12-hour intervals for not more than 3 doses, as indicated by clinical response.
2 Indications for use. For the treatment of mastitis caused by Streptococcus agalactiae, S.
dysgalactiae, and S. uberus in lactating cows.
3 Limitations. For intramammary infusion in lactating cows only. Discard all milk for 60 hours 5 milkings after the latest treatment. Animals intended for human consumption must not be slaughtered within 3 days of latest treatment.
e Conditions of use in dry cows1
Amount. Infuse the contents of one 10milliliter syringe equivalent to 100,000
units penicillin G into each infected quarter at time of drying-off.
2 Indications for use. For the treatment of mastitis caused by Streptococcus agalactiae in dry cows.
3 Limitations. For intramammary infusion in dry cows only. Animals intended for human consumption must not be slaughtered within 14 days of last treatment. Discard all milk for 72 hours 6 milkings following calving, or later as indicated by the marketable quality of the milk.
526.1696a

Removed
33. Remove 526.1696a.

526.1696b
Redesignated as 526.1697

34. Redesignate 526.1696b as 526.1697 and revise the section heading and paragraphs a and d and add paragraph e.
The revisions and addition read as follows:

526.1697 Penicillin G procaine and dihydrostreptomycin.

a Specifications. Each single-use, 10milliliter syringe contains a suspension of:

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1 Penicillin G procaine equivalent to 200,000 units penicillin G and dihydrostreptomycin sulfate equivalent to 300 milligrams dihydrostreptomycin;
or 2 Penicillin G procaine equivalent to 1 million units penicillin G and dihydrostreptomycin sulfate equivalent to 1 gram dihydrostreptomycin.

d Conditions of use for syringe described in paragraph a1 of this section in dry cows1 Amount. Infuse the contents of one syringe equivalent to 200,000 units penicillin G and 300
milligrams dihydrostreptomycin into each quarter at the last milking prior to drying off.
2 Indications for use. For the treatment of subclinical mastitis in dairy cows at the time of drying off, specifically against infections caused by Staphylococcus aureus and Streptococcus agalactiae.
3 Limitations. For use in dry cows only. Not to be used within 6 weeks of calving. Milk taken from cows within 24
hours 2 milkings after calving must not be used for food. Animals infused with this drug must not be slaughtered for food within 60 days of treatment or within 24 hours after calving.
e Conditions of use for syringe described in paragraph a2 of this section in dry cows1 Amount. Infuse the contents of one syringe equivalent to 1 million units penicillin G and 1
gram dihydrostreptomycin into each quarter at the last milking prior to drying off.
2 Indications for use. To reduce the frequency of existing infection and to prevent new infections with Staphylococcus aureus in dry cows.
3 Limitations. Not for use in lactating cows. Not to be used within 6
weeks of calving. Milk taken from cows within 96 hours 8 milkings after calving must not be used for food.
Animals infused with this drug must not be slaughtered for food within 60
days from the time of infusion or within 96 hours after calving. Federal law restricts this drug to use by or on the order of a licensed veterinarian.
526.1696c

Removed
35. Remove 526.1696c.

526.1696d
Redesignated as 526.1698

36. Redesignate 526.1696d as 526.1698 and revise the section heading and paragraphs a and d and add paragraph e.
The revisions and addition read as follows:

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