The 100 most highly cited papers of all time

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To mark the anniversary, Nature magazine asked Thomson Reuters to list the 100 most highly cited papers of all time. The search covered all of Thomson Reuter’s Web of Science, an online version of the SCI that also includes databases covering the social sciences, arts and humanities, conference proceedings and some books. It lists papers published from 1900 to the present day.

 
Title of the paperRankAsunto
Phosphorus assay in column chromatography.81Biology lab techniqueVer Más
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures.82CrystallographyVer Más
Van der Waals volumes and radii.83CrystallographyVer Más
A new and rapid colorimetric determination of acetylcholinesterase activity.84Biology lab techniqueVer Más
Projector augmented-wave method.85Physical chemistryVer Más
Optimization by simulated annealing.86Physical chemistryVer Más
Nitric oxide: physiology - pathophysiology - and pharmacology.87Biology lab techniqueVer Más
An algorithm for least-squares estimation of nonlinear parameters.88Mathematics/statisticsVer Más
Efficiency of ab initio total energy calculations for metals and semiconductors using a plane-wave basis set.89Physical chemistryVer Más
A low-cost - high-efficiency solar-cell based on dye-sensitized colloidal TiO2 films.90Physical chemistryVer Más
A low-viscosity epoxy resin embedding medium for electron microscopy.91Biology lab techniqueVer Más
The Protein Data Bank.92CrystallographyVer Más
Accurate and simple analytic representation of the electron-gas correlation-energy93Physical chemistryVer Más
Rapid alkaline extraction procedure for screening recombinant plasmid DNA.94Biology lab techniqueVer Más
Improved methods for building protein models in electron-density maps and the location of errors in these models.95CrystallographyVer Más
Accurate spin-dependent electron liquid correlation energies for local spin-density calculations — a critical analysis.96Physical chemistryVer Más
Continuous cultures of fused cells secreting antibody of predefined specificity.97Biology lab techniqueVer Más
Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.98MedicineVer Más
Adsorption of gases in multimolecular layers.99PhysicsVer Más
MrBayes 3: Bayesian phylogenetic inference under mixed models100PhylogeneticsVer Más

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